Over the last couple of years the link between SOD1 and sporadic MND has taken a back seat with the discovery of TDP-43 mutations in some familial cases of MND and TDP-43 pathology present in a large proportion of sporadic MND cases. Scientists had previously looked for accumulations of SOD1 in sporadic MND, as can be found in familial MND associated with SOD1, but with the available tools were unable to find any.

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