In this section you can find out more about motor neurone disease (MND), which is also known as amyotrophic lateral sclerosis (ALS) or Lou Gerig's disease in some countries.

Motor neurone disease (MND) is the name given to a group of diseases in which the nerve cells - neurones - controlling the muscles that enable us to move, speak, breathe and swallow; undergo degeneration and die.

Motor function is controlled by upper motor neurones (UMN) in the brain that descend to the spinal cord; these neurones activate anterior horn cells - lower motor neurones (LMN). The LMN exit the spinal cord and directly activate muscles. With no nerves to activate them, muscles gradually weaken and waste. The patterns of weakness vary from person to person.

Motor neurone disease occurs at similar rates in most countries of the world. It is estimated that there are presently around 400,000 people worldwide diagnosed with MND and about 2000 people with MND in Australia. Slightly more men than women are diagnosed with MND, most commonly in the 50 to 60 year age group. However, MND may be diagnosed in adults at any age.

Early symptoms of motor neurone disease are often mild. They may include:

  • stumbling due to weakness of the leg muscles
  • difficulty holding objects due to weakness of the hand muscles
  • slurring of speech or swallowing difficulties due to weakness of the tongue and throat muscles
  • cramps and muscle twitching (fasciculation).

The diagnosis of motor neurone disease is often clinically difficult, and sometimes it is necessary to review a person for some time before the diagnosis becomes relatively certain. A general practitioner may suspect a neurological problem, and organise referral to a neurologist.

MND takes several forms. For some people, the symptoms are widespread from the onset. However MND usually begins by affecting a single limb or aspect of motor function, becoming more generalised as the disease progresses.

There is no cure for MND, but a medication has been approved in Australia for people with amyotrophic lateral sclerosis (ALS) - the most common form of MND. This medication may extend a person’s survival time by a median of  two to three months.

The neurones carrying sensory messages of pain, touch, heat, cold and pressure from the skin and deeper tissues back to the spinal cord and brain are unaffected.

However, while most people experience little or no pain at any stage of the illness, others may experience some pain or discomfort such as:

The causes of motor neurone disease are not yet known, but ongoing research throughout the world is looking for causes.